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Joint pain is one of the most commonly reported pain types in the United States. In the case of patients suffering from inflammatory diseases such as osteoarthritis (OA) and gout, persistent inflammation due to long-term overexpression of several key cytokines has been linked to neuronal hypersensitivity and damage within the joints. Ultimately, a subset of patients develop chronic pain. Pharmacologic treatment of joint pain involves the use of analgesics such as acetaminophen, non-steroidal anti-inflammatory drugs (NSAIDs), opioids, antidepressants, as well as intra-articular injections of corticosteroids and hyaluronic acid. However, NSAIDs are short-acting and fail to alleviate severe pain, opioids are generally ineffective at managing chronic pain, and all therapeutic options involve increased risks of serious side effects.
Pubmed ID: 38952995
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Software that fits s-shaped psychometric functions to psychophysical data using a maximum-likelihood technique. The psychometric functions available are logistic, Weibull, Gaussian integral, cumulative Poisson and step. PsychoFit produces, among other things, files with graphic information suitable for importing in a graphic program for plotting.
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