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Combined IL6 and CCR2 blockade potentiates antitumor activity of NK cells in HPV-negative head and neck cancer.

Fan Yang | Chenyang Yuan | Fanghui Chen | Zhaohui S Qin | Nicole C Schmitt | Gregory B Lesinski | Nabil F Saba | Yong Teng
Journal of experimental & clinical cancer research : CR | 2024

While T cell-activating immunotherapies against recurrent head and neck squamous cell carcinoma (HNSCC) have shown impressive results in clinical trials, they are often ineffective in the majority of patients. NK cells are potential targets for immunotherapeutic intervention; however, the setback in monalizumab-based therapy in HNSCC highlights the need for an alternative treatment to enhance their antitumor activity.

Pubmed ID: 38468260

Research resources used in this publication

None found

Antibodies used in this publication

None found

Associated grants

  • Agency: NIDCR NIH HHS, United States
    Id: R03 DE028387
  • Agency: NIDCR NIH HHS, United States
    Id: R01DE028351
  • Agency: NIDCR NIH HHS, United States
    Id: R03 DE032084
  • Agency: NIDCR NIH HHS, United States
    Id: R01 DE033433
  • Agency: NIDCR NIH HHS, United States
    Id: R01 DE028351
  • Agency: NIDCR NIH HHS, United States
    Id: R03DE032084
  • Agency: NIDCR NIH HHS, United States
    Id: R01DE033691
  • Agency: NIDCR NIH HHS, United States
    Id: R01 DE033691
  • Agency: NIDCR NIH HHS, United States
    Id: R01DE033433

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FlowJo (tool)

RRID:SCR_008520

Software for single-cell flow cytometry analysis. Its functions include management, display, manipulation, analysis and publication of the data stream produced by flow and mass cytometers.

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RRID:SCR_012773

Integrated database resource consisting of 16 main databases, broadly categorized into systems information, genomic information, and chemical information. In particular, gene catalogs in completely sequenced genomes are linked to higher-level systemic functions of cell, organism, and ecosystem. Analysis tools are also available. KEGG may be used as reference knowledge base for biological interpretation of large-scale datasets generated by sequencing and other high-throughput experimental technologies.

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RRID:SCR_012931

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BD Biosciences (tool)

RRID:SCR_013311

An Antibody supplier

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ThermoFisher Scientific EVOS M5000 Imaging System (tool)

RRID:SCR_023650

Microsoft system includes integrated digital inverted benchtop microscope for four-color fluorescence, transmitted-light, and color imaging. Provides interchangeable optics with autofocus, single-click multi-channel image acquisition.3.2 Megapixels, monochrome, CMOS camera. Offers software for acquisition, analysis, and automated cell counting.

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RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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