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Safety, Pharmacokinetics, and Efficacy Signals of Larsucosterol (DUR-928) in Alcohol-Associated Hepatitis.

Tarek Hassanein | Craig J McClain | Vatsalya Vatsalya | Lance L Stein | Steven L Flamm | Paul Martin | Matthew C Cave | Mack Mitchell | Bruce Barton | Laura Nagy | Gyongyi Szabo | Arthur McCullough | Srinivasin Dasarathy | Jaymin Shah | Christina Blevins | Deborah Scott | William Krebs | James E Brown | WeiQi Lin
The American journal of gastroenterology | 2024

This study is to evaluate the safety and pharmacokinetics (PK) of larsucosterol (DUR-928 or 25HC3S) in subjects with alcohol-associated hepatitis (AH), a devastating acute illness without US Food and Drug Administration-approved therapies.

Pubmed ID: 37011138

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RRID:SCR_002309

Registry and results database of federally and privately supported clinical trials conducted in United States and around world. Provides information about purpose of trial, who may participate, locations, and phone numbers for more details. This information should be used in conjunction with advice from health care professionals.Offers information for locating federally and privately supported clinical trials for wide range of diseases and conditions. Research study in human volunteers to answer specific health questions. Interventional trials determine whether experimental treatments or new ways of using known therapies are safe and effective under controlled environments. Observational trials address health issues in large groups of people or populations in natural settings. ClinicalTrials.gov contains trials sponsored by National Institutes of Health, other federal agencies, and private industry. Studies listed in database are conducted in all 50 States and in 178 countries.

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