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Nna1/CCP1 is generally known as a causative gene for a spontaneous autosomal recessive mouse mutation, Purkinje cell degeneration (pcd). There is enough evidence that the cytosolic function of the zinc carboxypeptidase (CP) domain at the C-terminus of the Nna1 protein is associated with cell death. On the other hand, this molecule's two nuclear localization signals (NLSs) suggest some other functions exist. We generated exon 3-deficient mice (Nna1N KO), which encode a portion of the N-terminal NLS. Despite the frameshift occurring in these mice, there was an expression of the Nna1 protein lacking the N-terminal side. Surprisingly, the pcd phenotype did not occur in the Nna1N KO mouse. Behavioral analysis revealed that they were less anxious when assessed by the elevated plus maze and the light/dark box tests compared to the control. Furthermore, they showed impairments in context-dependent and sound stimulus-dependent learning. Biochemical analysis of Nna1N KO mice revealed a reduced level of the AMPA-type glutamine receptor GluA2 in the hippocampal synaptosomal fraction. In addition, the motor protein kinesin-1, which transports GluA2 to dendrites, was also decreased. These results indicate that Nna1 is also involved in emotion and memory learning, presumably through the trafficking and expression of synaptic signaling molecules, besides a known role in cell survival.
Pubmed ID: 36361749
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NIH genetic sequence database that provides annotated collection of all publicly available DNA sequences for almost 280 000 formally described species (Jan 2014) .These sequences are obtained primarily through submissions from individual laboratories and batch submissions from large-scale sequencing projects, including whole-genome shotgun (WGS) and environmental sampling projects. Most submissions are made using web-based BankIt or standalone Sequin programs, and GenBank staff assigns accession numbers upon data receipt. It is part of International Nucleotide Sequence Database Collaboration and daily data exchange with European Nucleotide Archive (ENA) and DNA Data Bank of Japan (DDBJ) ensures worldwide coverage. GenBank is accessible through NCBI Entrez retrieval system, which integrates data from major DNA and protein sequence databases along with taxonomy, genome, mapping, protein structure and domain information, and biomedical journal literature via PubMed. BLAST provides sequence similarity searches of GenBank and other sequence databases. Complete bimonthly releases and daily updates of GenBank database are available by FTP.
View all literature mentionsPublic image processing and analysis program for Macintosh.
View all literature mentionsCommercial vendor and service provider of laboratory reagents and antibodies. Supplier of scientific instrumentation, reagents and consumables, and software services.
View all literature mentionsAmerican chemical, life science and biotechnology company owned by Merck KGaA. Merger of Sigma Chemical Company and Aldrich Chemical Company. Provides organic and inorganic chemicals, building blocks, reagents, advanced materials and stable isotopes for chemical synthesis, medicinal chemistry and materials science, antibiotics, buffers, carbohydrates, enzymes, forensic tools, hematology and histology, nucleotides, proteins, peptides, amino acids and their derivatives.
View all literature mentionsAn Antibody supplier; Dako was purchased by Agilent in 2012 and several years later the websites began to reflect the Dako products as part of the Agilent catalog.
View all literature mentionslaboratory mouse with name C57BL/6N from MGI.
View all literature mentionsThis polyclonal secondary targets IgG
View all literature mentionsThis monoclonal targets Kinesin, Heavy Chain
View all literature mentionsThis polyclonal targets mouse GluA4, N-terminal 262-294 aa (AB022913)
View all literature mentionsThis monoclonal targets Tubulin Polyglutamylated antibody produced in mouse
View all literature mentionsThis polyclonal targets IgG
View all literature mentionsThis polyclonal targets mouse GluA3, 853-883 aa (AB022342)
View all literature mentionsThis monoclonal targets actin
View all literature mentionsThis polyclonal targets mouse GluR2, C-terminal 847-863 aa (X57498)
View all literature mentionsThis polyclonal targets mouse GluA1, 841-907 aa (X57497)
View all literature mentionsThis polyclonal targets mouse GLAST, C-terminal 41 aa (NM148938)
View all literature mentionsThis polyclonal targets mouse Car8, 33-61 aa (BC010773)
View all literature mentionsThis polyclonal targets mouse GluA3, 853-883 aa (AB022342)
View all literature mentionslaboratory mouse with name Slc:ICR from MGI.
View all literature mentionsThis polyclonal targets mouse GluA4, N-terminal 262-294 aa (AB022913)
View all literature mentionsStrain Type: Not Specified This is a legacy resource.
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