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In vitro and in vivo Evaluation of a Novel Estrogen-Targeted PEGylated Oxaliplatin Liposome for Gastric Cancer.

Yuxin Sun | Yizhuo Xie | Huan Tang | Zhihui Ren | Xue Luan | Yan Zhang | Ming Zhu | Zhe Lv | Han Bao | Yan Li | Rui Liu | Yujia Shen | Yucui Zheng | Jin Pei
International journal of nanomedicine | 2021

Chemotherapy is still the main first-line treatment for advanced metastatic gastric cancer, but it has the limitations of serious side effects and drug resistance. Conventional liposome has been substantially used as drug carriers, but they lack targeting character with lower drug bioavailability in tumor tissues. Based on the above problems, a novel estrogen-targeted PEGylated liposome loaded with oxaliplatin (ES-SSL-OXA) was prepared to further improve the metabolic behavior, the safety profile, and the anti-tumor efficacy of oxaliplatin.

Pubmed ID: 34992365

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This is a list of tools and resources that we have found mentioned in this publication.


SGC-7901 (tool)

RRID:CVCL_0520

Cell line SGC-7901 is a Cancer cell line with a species of origin Homo sapiens

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BALB/cAnNCrl (tool)

RRID:MGI:2683685

laboratory mouse with name BALB/cAnNCrl from MGI.

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