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Genome-wide analysis of DNA methylation in 106 schizophrenia family trios in Han Chinese.

Lu Shen | Xiaoying Lv | Hailiang Huang | Mo Li | Cong Huai | Xi Wu | Hao Wu | Jingsong Ma | Luan Chen | Ting Wang | Jie Tan | Yidan Sun | Lixing Li | Yi Shi | Chao Yang | Lei Cai | Yana Lu | Yan Zhang | Saizheng Weng | Shaobin Tai | Na Zhang | Lin He | Chunling Wan | Shengying Qin
EBioMedicine | 2021

Schizophrenia (SCZ) is a severe psychiatric disorder that affects approximately 0.75% of the global population. Both genetic and environmental factors contribute to development of SCZ. SCZ tends to run in family while both genetic and environmental factor contribute to its etiology. Much evidence suggested that alterations in DNA methylations occurred in SCZ patients.

Pubmed ID: 34628353

Research resources used in this publication

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Antibodies used in this publication

None found

Associated grants

None

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This is a list of tools and resources that we have found mentioned in this publication.


Cytoscape (tool)

RRID:SCR_003032

Software platform for complex network analysis and visualization. Used for visualization of molecular interaction networks and biological pathways and integrating these networks with annotations, gene expression profiles and other state data.

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STRING (tool)

RRID:SCR_005223

Database of known and predicted protein interactions. The interactions include direct (physical) and indirect (functional) associations and are derived from four sources: Genomic Context, High-throughput experiments, (Conserved) Coexpression, and previous knowledge. STRING quantitatively integrates interaction data from these sources for a large number of organisms, and transfers information between these organisms where applicable. The database currently covers 5''214''234 proteins from 1133 organisms. (2013)

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BEDTools (tool)

RRID:SCR_006646

A powerful toolset for genome arithmetic allowing one to address common genomics tasks such as finding feature overlaps and computing coverage. Bedtools allows one to intersect, merge, count, complement, and shuffle genomic intervals from multiple files in widely-used genomic file formats such as BAM, BED, GFF/GTF, VCF. While each individual tool is designed to do a relatively simple task (e.g., intersect two interval files), quite sophisticated analyses can be conducted by combining multiple bedtools operations on the UNIX command line.

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CEAS (tool)

RRID:SCR_010946

Integrates many useful tools to simplify ChIP-chip analysis for biologists.

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KEGG (tool)

RRID:SCR_012773

Integrated database resource consisting of 16 main databases, broadly categorized into systems information, genomic information, and chemical information. In particular, gene catalogs in completely sequenced genomes are linked to higher-level systemic functions of cell, organism, and ecosystem. Analysis tools are also available. KEGG may be used as reference knowledge base for biological interpretation of large-scale datasets generated by sequencing and other high-throughput experimental technologies.

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Agilent Feature Extraction Software (tool)

RRID:SCR_014963

Software that automatically reads and processes up to 100 raw microarray image files. The software finds and places microarray grids, rejects outlier pixels, accurately determines feature intensities and ratios, flags outlier pixels, and calculates statistical confidences.

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Agilent SureScan Dx Microarray Scanner (tool)

RRID:SCR_019544

SureScan Dx microarray scanner system analyzes many genomics and cytogenetics microarrays.

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