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Publication

MST4 attenuates NLRP3 inflammasome-mediated neuroinflammation and affects the prognosis after intracerebral hemorrhage in mice.

Xiaodong Wu | Yan Zhang | Yulong Zhang | Lei Xia | Yating Yang | Ping Wang | Yang Xu | Zhenhua Ren | Huanzhong Liu
Brain research bulletin | 2021

The kinase MST4 limits inflammatory responses through direct phosphorylation of the adaptor TRAF6. TRAF6 interacts with NLRP3 to promote the activation of NLRP3 inflammasome. However, the role of MST4 in neuroinflammation after intracerebral hemorrhage (ICH) and how it interacts with NLRP3 inflammasome remain unclear.

Pubmed ID: 34534636

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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