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Bufalin induces mitochondrial dysfunction and promotes apoptosis of glioma cells by regulating Annexin A2 and DRP1 protein expression.

Yao Li | Yan Zhang | Xufang Wang | Qian Yang | Xuanxuan Zhou | Junsheng Wu | Xu Yang | Yani Zhao | Rui Lin | Yanhua Xie | Jiani Yuan | Xiaohui Zheng | Siwang Wang
Cancer cell international | 2021

Glioma is a common primary central nervous system tumour, and therapeutic drugs that can effectively improve the survival rate of patients in the clinic are lacking. Bufalin is effective in treating various tumours, but the mechanism by which it promotes the apoptosis of glioma cells is unclear. The aim of this study was to investigate the drug targets of bufalin in glioma cells and to clarify the apoptotic mechanism.

Pubmed ID: 34376212

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