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Endothelial damage in septic shock patients as evidenced by circulating syndecan-1, sphingosine-1-phosphate and soluble VE-cadherin: a substudy of ALBIOS.

Arianna Piotti | Deborah Novelli | Jennifer Marie Theresia Anna Meessen | Daniela Ferlicca | Sara Coppolecchia | Antonella Marino | Giovanni Salati | Monica Savioli | Giacomo Grasselli | Giacomo Bellani | Antonio Pesenti | Serge Masson | Pietro Caironi | Luciano Gattinoni | Marco Gobbi | Claudia Fracasso | Roberto Latini | ALBIOS Investigators
Critical care (London, England) | 2021

Septic shock is characterized by breakdown of the endothelial glycocalyx and endothelial damage, contributing to fluid extravasation, organ failure and death. Albumin has shown benefit in septic shock patients. Our aims were: (1) to identify the relations between circulating levels of syndecan-1 (SYN-1), sphingosine-1-phosphate (S1P) (endothelial glycocalyx), and VE-cadherin (endothelial cell junctions), severity of the disease, and survival; (2) to evaluate the effects of albumin supplementation on endothelial dysfunction in patients with septic shock.

Pubmed ID: 33741039

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MassLynx (tool)

RRID:SCR_014271

Software which can acquire, analyze, manage, and share mass spectrometry data. MassLynx controls any Waters mass spectrometry system, from sample and solvent management components to mass spectrometer and auxiliary detectors. The software can acquire nominal mass, exact mass, MS/MS and exact mass MS/MS data. The software system also maintains and consolidates all user sample data. Optional Application Manager programs provide additional information for specific MS analyses and data.

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