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Downregulation of lncRNA ZNF582-AS1 due to DNA hypermethylation promotes clear cell renal cell carcinoma growth and metastasis by regulating the N(6)-methyladenosine modification of MT-RNR1.

Wuping Yang | Kenan Zhang | Lei Li | Yawei Xu | Kaifang Ma | Haibiao Xie | Jingcheng Zhou | Lin Cai | Yanqing Gong | Kan Gong
Journal of experimental & clinical cancer research : CR | 2021

Emerging evidence confirms that lncRNAs (long non-coding RNAs) are potential biomarkers that play vital roles in tumors. ZNF582-AS1 is a novel lncRNA that serves as a potential prognostic marker of cancers. However, the specific clinical significance and molecular mechanism of ZNF582-AS1 in ccRCC (clear cell renal cell carcinoma) are unclear.

Pubmed ID: 33691743

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