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Contrasting effects of the α7 nicotinic receptor antagonist methyllycaconitine in different rat models of heroin reinstatement.

Josephine Palandri | Sharon L Smith | David J Heal | Sue Wonnacott | Chris P Bailey
Journal of psychopharmacology (Oxford, England) | 2021

α7 Nicotinic acetylcholine receptors are implicated in the reinstatement of drug-seeking, an important component of relapse. We showed previously that the α7 nicotinic acetylcholine receptor antagonist, methyllycaconitine, specifically attenuated morphine-primed reinstatement of conditioned place preference in rodents and this effect was mediated in the ventral hippocampus.

Pubmed ID: 33691518

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