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Ubiquitin-specific protease 7 as a potential therapeutic target in dogs with hematopoietic malignancies.

Aleksandra Pawlak | Joanna Bajzert | Katarzyna Bugiel | Beatriz Hernández Suárez | Justyna Kutkowska | Andrzej Rapak | Wojciech Hildebrand | Bożena Obmińska-Mrukowicz | Raimundo Freire | Veronique A J Smits
Journal of veterinary internal medicine | 2021

Ubiquitin-specific protease 7 (USP7) belongs to the group of deubiquitinating enzymes (DUBs), which remove ubiquitin which controls various cellular processes such as chromosome segregation, DNA repair, gene expression, protein localization, kinase activity, protein degradation, cell cycle progression, and apoptosis. It is critical for several important functions in the cell, and therefore dysregulation of USP7 can contribute to tumorigenesis.

Pubmed ID: 33650720

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