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Preclinical evaluation of cancer immune therapy using patient-derived tumor antigen-specific T cells in a novel xenograft platform.

Gautam N Shenoy | Christopher J Greene | Maulasri Bhatta | Miren L Baroja | Jenni L Loyall | Sathy V Balu-Iyer | Raymond J Kelleher | Beatriz M Carreno | Gerald P Linette | Leonard D Shultz | Richard B Bankert
Clinical & translational immunology | 2021

With a rapidly growing list of candidate immune-based cancer therapeutics, there is a critical need to generate highly reliable animal models to preclinically evaluate the efficacy of emerging immune-based therapies, facilitating successful clinical translation. Our aim was to design and validate a novel in vivo model (called Xenomimetic or 'X' mouse) that allows monitoring of the ability of human tumor-specific T cells to suppress tumor growth following their entry into the tumor.

Pubmed ID: 33552509

Associated grants

  • Agency: NIAID NIH HHS, United States
    Id: R01 AI132963
  • Agency: NCI NIH HHS, United States
    Id: P30 CA034196
  • Agency: NCI NIH HHS, United States
    Id: R21 CA205794
  • Agency: NIH HHS, United States
    Id: R24 OD026440
  • Agency: NCI NIH HHS, United States
    Id: R43 CA257721
  • Agency: NCI NIH HHS, United States
    Id: R01 CA131407
  • Agency: NCI NIH HHS, United States
    Id: R43 CA224602
  • Agency: NCI NIH HHS, United States
    Id: R01 CA204261

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SigmaPlot (tool)

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