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Publication

Inhibition of platelet adhesion, thrombus formation, and fibrin formation by a potent αIIbβ3 integrin inhibitor from ticks.

Danique L van den Kerkhof | Magdolna Nagy | Kanin Wichapong | Sanne L N Brouns | Johan W M Heemskerk | Tilman M Hackeng | Ingrid Dijkgraaf
Research and practice in thrombosis and haemostasis | 2021

Ticks puncture the skin of their hosts and secrete saliva, containing antiplatelet proteins, into the blood. Here, we studied disagregin, a potent platelet-inhibiting protein derived from the salivary glands of Ornithodoros moubata, an African soft tick. Whereas conventional αIIbβ3 antagonists contain an Arg-Gly-Asp (RGD) sequence for platelet integrin binding, disagregin contains an Arg-Glu-Asp (RED) sequence, hypothesizing a different mode of inhibitory action.

Pubmed ID: 33537548

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