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Systemic Immunomodulatory Effects of Combinatorial Treatment of Thalidomide and Dexamethasone on T Cells and Other Immune Cells.

Eun Jee Kim | Joon Ye Kim | Hoon Young Choi | Hyojung Lee | Juhan Lee | Myoung Soo Kim | Yu Seun Kim | Kyu Ha Huh | Beom Seok Kim
Yonsei medical journal | 2021

In organ transplantation, the need for immune modulation rather than immune suppression has been emphasized. In this study, we investigated whether combinatorial treatments of with thalidomide (TM) and dexamethasone (DX) might be new approaches to induce systemic immunomodulation on T cells and other immune cells that regulate the expression of co-inhibitory molecules.

Pubmed ID: 33527793

Research resources used in this publication

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Associated grants

  • Agency: Korea Health Industry Development Institute, Republic of Korea
    Id: HI18C0629
  • Agency: Yonsei University College of Medicine, Korea
    Id: 6-2018-0106
  • Agency: Korean Society for Transplantation, Korea
    Id: 161028

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FlowJo (tool)

RRID:SCR_008520

Software for single-cell flow cytometry analysis. Its functions include management, display, manipulation, analysis and publication of the data stream produced by flow and mass cytometers.

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American chemical, life science and biotechnology company owned by Merck KGaA. Merger of Sigma Chemical Company and Aldrich Chemical Company. Provides organic and inorganic chemicals, building blocks, reagents, advanced materials and stable isotopes for chemical synthesis, medicinal chemistry and materials science, antibiotics, buffers, carbohydrates, enzymes, forensic tools, hematology and histology, nucleotides, proteins, peptides, amino acids and their derivatives.

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BD Biosciences (tool)

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Mus musculus with name C57BL/6J from IMSR.

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BALB/cAnNCrl (tool)

RRID:MGI:2683685

laboratory mouse with name BALB/cAnNCrl from MGI.

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