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Publication

Targeting UBC9-mediated protein hyper-SUMOylation in cystic cholangiocytes halts polycystic liver disease in experimental models.

Pui Y Lee-Law | Paula Olaizola | Francisco J Caballero-Camino | Laura Izquierdo-Sanchez | Pedro M Rodrigues | Alvaro Santos-Laso | Mikel Azkargorta | Felix Elortza | Maria L Martinez-Chantar | Maria J Perugorria | Patricia Aspichueta | Marco Marzioni | Nicholas F LaRusso | Luis Bujanda | Joost P H Drenth | Jesus M Banales
Journal of hepatology | 2021

Polycystic liver diseases (PLDs) are genetic disorders characterized by progressive development of multiple fluid-filled biliary cysts. Most PLD-causative genes participate in protein biogenesis and/or transport. Post-translational modifications (PTMs) are implicated in protein stability, localization and activity, contributing to human pathobiology; however, their role in PLD is unknown. Herein, we aimed to unveil the role of protein SUMOylation in PLD and its potential therapeutic targeting.

Pubmed ID: 32950589

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Associated grants

  • Agency: NIDDK NIH HHS, United States
    Id: P30 DK084567
  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK024031

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RRID:RGD_70508

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