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Publication

Liver Pyruvate Kinase Promotes NAFLD/NASH in Both Mice and Humans in a Sex-Specific Manner.

Karthickeyan Chella Krishnan | Raquel R Floyd | Simon Sabir | Dulshan W Jayasekera | Paola V Leon-Mimila | Anthony E Jones | Angel A Cortez | Varun Shravah | Miklós Péterfy | Linsey Stiles | Samuel Canizales-Quinteros | Ajit S Divakaruni | Adriana Huertas-Vazquez | Aldons J Lusis
Cellular and molecular gastroenterology and hepatology | 2021

The etiology of nonalcoholic fatty liver disease (NAFLD) is poorly understood, with males and certain populations exhibiting markedly increased susceptibility. Using a systems genetics approach involving multi-omic analysis of ∼100 diverse inbred strains of mice, we recently identified several candidate genes driving NAFLD. We investigated the role of one of these, liver pyruvate kinase (L-PK or Pklr), in NAFLD by using patient samples and mouse models.

Pubmed ID: 32942044

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None found

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Associated grants

  • Agency: NIDDK NIH HHS, United States
    Id: K99 DK120875
  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK117850
  • Agency: NHLBI NIH HHS, United States
    Id: P01 HL028481
  • Agency: NIDDK NIH HHS, United States
    Id: P30 DK063491
  • Agency: NIDDK NIH HHS, United States
    Id: R00 DK120875
  • Agency: NCI NIH HHS, United States
    Id: T32 CA009056
  • Agency: NIGMS NIH HHS, United States
    Id: R35 GM138003

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Bioconductor (tool)

RRID:SCR_006442

Software repository for R packages related to analysis and comprehension of high throughput genomic data. Uses separate set of commands for installation of packages. Software project based on R programming language that provides tools for analysis and comprehension of high throughput genomic data.

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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