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Publication

IL-10 production by ILC2s requires Blimp-1 and cMaf, modulates cellular metabolism, and ameliorates airway hyperreactivity.

Emily Howard | Gavin Lewis | Lauriane Galle-Treger | Benjamin P Hurrell | Doumet Georges Helou | Pedram Shafiei-Jahani | Jacob D Painter | German Aleman Muench | Pejman Soroosh | Omid Akbari
The Journal of allergy and clinical immunology | 2021

Group 2 innate lymphoid cells (ILC2s) are the dominant innate lymphoid cell population in the lungs at steady state, and their release of type 2 cytokines is a central driver in responding eosinophil infiltration and increased airway hyperreactivity. Our laboratory has identified a unique subset of ILC2s in the lungs that actively produce IL-10 (ILC210s).

Pubmed ID: 32905799

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Associated grants

  • Agency: NIEHS NIH HHS, United States
    Id: R01 ES021801
  • Agency: NHLBI NIH HHS, United States
    Id: R01 HL144790
  • Agency: NHLBI NIH HHS, United States
    Id: R01 HL159804
  • Agency: NIAID NIH HHS, United States
    Id: R21 AI109059
  • Agency: NIEHS NIH HHS, United States
    Id: R01 ES025786

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Bio X Cell (tool)

RRID:SCR_004997

Commercial supplier and developer of in vivo antibodies. Provides antibodies and antibody production services.

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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BALB/cByJ (tool)

RRID:IMSR_JAX:001026

Mus musculus with name BALB/cByJ from IMSR.

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