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Publication

Antibody response to homologous epitopes of Epstein-Barr virus, Mycobacterium avium subsp. paratuberculosis and IRF5 in patients with different connective tissue diseases and in mouse model of antigen-induced arthritis.

Marco Bo | Magdalena Niegowska | Hayley L Eames | Hannah Almuttaqi | Giannina Arru | Gian Luca Erre | Giuseppe Passiu | Tariq E Khoyratty | Erinke van Grinsven | Irina A Udalova | Leonardo A Sechi
Journal of translational autoimmunity | 2020

Improved knowledge of different biomarkers is crucial for early diagnosis of rheumatic diseases and to provide important insights for clinical management. In this study, we evaluated the seroreactivity of patients with different connective tissue diseases (CTDs) (rheumatoid arthritis, RA; systemic lupus erythematosus, SLE; systemic sclerosis, SSc; and Sjogren's syndrome, SSj) to interferon regulatory factor 5 (IRF5) peptide and homologs derived from Epstein-Barr virus (EBV) and Mycobacterium avium subsp. paratuberculosis (MAP). Antigen-induced arthritis (AIA) experiments have been performed in control and IRF5 conditional knockout mice to reinforce the hypothesis that antibodies generated against the three homologous peptides are cross-reactive.

Pubmed ID: 32743529

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STOCK Lyz2tm1(cre/ERT2)Grtn/J (tool)

RRID:IMSR_JAX:031674

Mus musculus with name STOCK Lyz2tm1(cre/ERT2)Grtn/J from IMSR.

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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C57BL/6-Irf5tm1Ppr/J (tool)

RRID:IMSR_JAX:017311

Mus musculus with name C57BL/6-Irf5tm1Ppr/J from IMSR.

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