Searching the Resource Information Network
Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.
DEAD-Box Helicase 3 X-Linked (DDX3X) is frequently mutated in the Wingless (WNT) and Sonic hedghog (SHH) subtypes of medulloblastoma-the commonest malignant childhood brain tumor, but whether DDX3X functions as a medulloblastoma oncogene or tumor suppressor gene is not known. Here, we show that Ddx3x regulates hindbrain patterning and development by controlling Hox gene expression and cell stress signaling. In mice predisposed to Wnt- or Shh medulloblastoma, Ddx3x sensed oncogenic stress and suppressed tumor formation. WNT and SHH medulloblastomas normally arise only in the lower and upper rhombic lips, respectively. Deletion of Ddx3x removed this lineage restriction, enabling both medulloblastoma subtypes to arise in either germinal zone. Thus, DDX3X is a medulloblastoma tumor suppressor that regulates hindbrain development and restricts the competence of cell lineages to form medulloblastoma subtypes.
Pubmed ID: 32553121
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
Software that calls aberrations for array CGH data using a six state mixture model and several biological concepts. It is written in R.
View all literature mentionsSoftware package for quantitative DNA sequencing for chromosomal aberrations providing a robust, cost-effective WGS method for DNA copy number analysis. The genome is divided into non-overlapping fixed-sized bins, number of sequence reads in each counted, adjusted with a simultaneous two-dimensional loess correction for sequence mappability and GC content, and filtered to remove spurious regions in the genome. Downstream steps of segmentation and calling are also implemented via packages DNAcopy and CGHcall, respectively.
View all literature mentionsSoftware that segments DNA copy number data using circular binary segmentation to detect regions with abnormal copy number.
View all literature mentionsThis monoclonal targets Mouse CD68
View all literature mentionsThis unknown targets Ki-67
View all literature mentionsThis polyclonal targets Iba1
View all literature mentionsThis polyclonal targets CD3
View all literature mentionsThis polyclonal targets GFAP
View all literature mentionsThis monoclonal targets IRF1
View all literature mentionsThis polyclonal targets DDX3
View all literature mentionsThis monoclonal targets Casp3
View all literature mentionsThis monoclonal targets G3BP1
View all literature mentionsThis monoclonal targets Human LEF-1 / TCF-1 alpha
View all literature mentionsThis polyclonal targets Mouse Mouse IgG secondary - H&L
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis monoclonal targets RAT ANTI MOUSE F4/80
View all literature mentionsThis unknown targets IgG
View all literature mentionsThis monoclonal targets CD45 antibody [I3/2.3]
View all literature mentionsThis polyclonal targets Contactin-2 / TAG1
View all literature mentionsThis polyclonal targets β-actin
View all literature mentionsThis unknown targets Rabbit IgG (H+L)
View all literature mentionsThis monoclonal targets Synaptophysin
View all literature mentionsThis monoclonal targets Ki-67
View all literature mentionsThis polyclonal targets Ki67 antibody - Proliferation Marker
View all literature mentionsThis unknown targets Rabbit IgG (H+L)
View all literature mentionsThis polyclonal targets Calbindin D-28K
View all literature mentionsThis unknown targets Pax-6
View all literature mentionsMus musculus with name Crl:CD1-Foxn1NU from IMSR.
View all literature mentionsMus musculus with name B6N.129-Ptch1tm1Hahn/J from IMSR.
View all literature mentions