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Mesenchymal stem cells transfected with sFgl2 inhibit the acute rejection of heart transplantation in mice by regulating macrophage activation.

Chao Gao | Xiaodong Wang | Jian Lu | Zhilin Li | Haowen Jia | Minghao Chen | Yuchen Chang | Yanhong Liu | Peiyuan Li | Baotong Zhang | Xuezhi Du | Feng Qi
Stem cell research & therapy | 2020

Mesenchymal stem cells (MSCs) have become a promising candidate for cell-based immune therapy for acute rejection (AR) after heart transplantation due to possessing immunomodulatory properties. In this study, we evaluated the efficacy of soluble fibronectin-like protein 2 (sFgl2) overexpressing mesenchymal stem cells (sFgl2-MSCs) in inhibiting AR of heart transplantation in mice by regulating immune tolerance through inducing M2 phenotype macrophage polarization.

Pubmed ID: 32552823

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