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Proangiogenic Hypoxia-Mimicking Agents Attenuate Osteogenic Potential of Adipose Stem/Stromal Cells.

Ahmed G Abu-Shahba | Arjen Gebraad | Sippy Kaur | Riku O Paananen | Hilkka Peltoniemi | Riitta Seppänen-Kaijansinkko | Bettina Mannerström
Tissue engineering and regenerative medicine | 2020

Insufficient vascularization hampers bone tissue engineering strategies for reconstructing large bone defects. Delivery of prolyl-hydroxylase inhibitors (PHIs) is an interesting approach to upregulate vascular endothelial growth factor (VEGF) by mimicking hypoxic stabilization of hypoxia-inducible factor-1alpha (HIF-1α). This study assessed two PHIs: dimethyloxalylglycine (DMOG) and baicalein for their effects on human adipose tissue-derived mesenchymal stem/stromal cells (AT-MSCs).

Pubmed ID: 32449039

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Associated grants

  • Agency: Ministry of Higher Education, Egypt, International
    Id: 290243/2014-2015
  • Agency: Helsingin Yliopisto, International
    Id: WBS490302
  • Agency: Helsingin Yliopisto, International
    Id: WBS73714112
  • Agency: Helsingin ja Uudenmaan Sairaanhoitopiiri, International
    Id: Y1014SUL05
  • Agency: Helsingin ja Uudenmaan Sairaanhoitopiiri, International
    Id: TYH2016130

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QIAGEN (tool)

RRID:SCR_008539

A commercial organization which provides assay technologies to isolate DNA, RNA, and proteins from any biological sample. Assay technologies are then used to make specific target biomolecules, such as the DNA of a specific virus, visible for subsequent analysis.

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MP Biomedicals (tool)

RRID:SCR_013308

An Antibody supplier

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