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Publication

CD133 inhibition via autophagic degradation in pemetrexed-resistant lung cancer cells by GMI, a fungal immunomodulatory protein from Ganoderma microsporum.

I-Lun Hsin | Ling-Yen Chiu | Chu-Chyn Ou | Wen-Jun Wu | Gwo-Tarng Sheu | Jiunn-Liang Ko
British journal of cancer | 2020

Adaptive drug resistance is an unfavourable prognostic factor in cancer therapy. Pemetrexed-resistant lung cancer cells possess high-metastatic ability via ERK-ZEB1 pathway-activated epithelial-mesenchymal transition. GMI is a fungal immunomodulatory protein that suppresses the survival of several cancer cells.

Pubmed ID: 32448867

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