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ApoA-1 improves glucose tolerance by increasing glucose uptake into heart and skeletal muscle independently of AMPKα2.

Andreas Mæchel Fritzen | Joan Domingo-Espín | Anne-Marie Lundsgaard | Maximilian Kleinert | Ida Israelsen | Christian S Carl | Trine S Nicolaisen | Rasmus Kjøbsted | Jacob F Jeppesen | Jørgen F P Wojtaszewski | Jens O Lagerstedt | Bente Kiens
Molecular metabolism | 2020

Acute administration of the main protein component of high-density lipoprotein, apolipoprotein A-I (ApoA-1), improves glucose uptake in skeletal muscle. The molecular mechanisms mediating this are not known, but in muscle cell cultures, ApoA-1 failed to increase glucose uptake when infected with a dominant-negative AMP-activated protein kinase (AMPK) virus. We therefore investigated whether AMPK is necessary for ApoA-1-stimulated glucose uptake in intact heart and skeletal muscle in vivo.

Pubmed ID: 32244181

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Mus musculus with name C57BL/6J from IMSR.

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Mus musculus with name C57BL/6J from IMSR.

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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