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The etiology of aortic aneurysms is poorly understood, but it is associated with atherosclerosis, hypercholesterolemia, and abnormal transforming growth factor β (TGF-β) signaling in smooth muscle. Here, we investigated the interactions between these different factors in aortic aneurysm development and identified a key role for smooth muscle cell (SMC) reprogramming into a mesenchymal stem cell (MSC)-like state. SMC-specific ablation of TGF-β signaling in Apoe-/- mice on a hypercholesterolemic diet led to development of aortic aneurysms exhibiting all the features of human disease, which was associated with transdifferentiation of a subset of contractile SMCs into an MSC-like intermediate state that generated osteoblasts, chondrocytes, adipocytes, and macrophages. This combination of medial SMC loss with marked increases in non-SMC aortic cell mass induced exuberant growth and dilation of the aorta, calcification and ossification of the aortic wall, and inflammation, resulting in aneurysm development.
Pubmed ID: 32243809
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Set of software modules for performing common ChIP-seq data analysis tasks across the whole genome, including positional correlation analysis, peak detection, and genome partitioning into signal-rich and signal-poor regions. The tools are designed to be simple, fast and highly modular. Each program carries out a well defined data processing procedure that can potentially fit into a pipeline framework. ChIP-Seq is also freely available on a Web interface.
View all literature mentionsA free reference manager and academic social network to organize your research, collaborate with others online, and discover the latest research. Automatically generate bibliographies, Collaborate easily with other researchers online, Easily import papers from other research software, Find relevant papers based on what you're reading, Access your papers from anywhere online, Read papers on the go with the iPhone app. The software, Mendeley Desktop, offers: * Automatic extraction of document details * Efficient management of your papers * Sharing and synchronization of your library (or parts of it) * Additional features: A plug-in for citing your articles in Microsoft Word, OCR (image-to-text conversion, so you can full-text search all your scanned PDFs), etc The website, Mendeley Web, complements Mendeley Desktop by offering these features: * An online back up of your library * Statistics of all things interesting * A research network that allows you to keep track of your colleagues' publications, conference participations, awards etc * A recommendation engine for papers that might interest you
View all literature mentionsA cloud-based platform which allows users to analyze, visualize, and archive multiparamter cytometry data for single-cell biology. Multiple single-cell data sets can be analyzed and visualized simultaneously with a variety of graphics, inlcuding Sunburst, SPADE, and viSNE. Users can store and back up related data such as protocols, microscopy images, and presentations and collaborate and share analysis and data sets with other Cytobank users. Cytobank also provides a variety of services and training sessions to assist with experiment workflow.
View all literature mentionsMus musculus with name B6.129P2-Apoetm1Unc/J from IMSR.
View all literature mentionsThis polyclonal targets Smad3
View all literature mentionsThis monoclonal targets Ly-6A / E
View all literature mentionsThis monoclonal targets GFP
View all literature mentionsThis monoclonal targets CD44
View all literature mentionsThis monoclonal targets Adiponectin
View all literature mentionsThis polyclonal targets Mouse Endoglin/CD105 Affinity Purified Ab
View all literature mentionsThis unknown targets Synthetic peptide: CKSKKFRRPDIQYPD, corresponding to amino acids 170-183 of Human Osteopontin. (Peptide available as ab9078).
View all literature mentionsThis monoclonal targets MAC-2/Gal-3
View all literature mentionsThis monoclonal targets smooth muscle Myosin heavy chain I
View all literature mentionsThis monoclonal targets Smad2 / 3
View all literature mentionsThis polyclonal targets Myh11
View all literature mentionsThis polyclonal targets GFPuv
View all literature mentionsThis polyclonal targets Apolipoprotein B
View all literature mentionsThis monoclonal targets RNA pol II CTD
View all literature mentionsThis monoclonal targets VCAM1
View all literature mentionsThis polyclonal targets Smad2 phospho-specific (Ser465/467)
View all literature mentionsThis monoclonal targets Mac2
View all literature mentionsThis unknown targets epitope mapping at the C-terminus of PECAM-1 of human origin
View all literature mentionsThis polyclonal targets RFP
View all literature mentionsThis monoclonal targets Smad2/3 (D7G7) XP Rabbit mAb
View all literature mentionsThis polyclonal targets HSP90AB1 (Ab-254) antibody produced in rabbit
View all literature mentionsThis monoclonal targets CD73
View all literature mentionsThis monoclonal targets Lubricin/Proteoglycan 4
View all literature mentionsThis polyclonal targets Human Smad3, phospho (Ser423 / Ser425)
View all literature mentionsThis polyclonal targets Adiponectin
View all literature mentionsThis monoclonal targets SOX9
View all literature mentionsThis polyclonal targets Phospho-Smad2 (Ser465/467)
View all literature mentionsThis polyclonal targets Timp3
View all literature mentionsThis monoclonal targets CD90 / Thy1
View all literature mentionsThis monoclonal targets CD68
View all literature mentionsThis polyclonal targets MMP2
View all literature mentionsThis monoclonal targets MYH11
View all literature mentionsThis monoclonal targets BrdU
View all literature mentionsThis monoclonal targets PPAR-gamma
View all literature mentionsThis monoclonal targets galectin-3
View all literature mentionsThis polyclonal targets Collagen II
View all literature mentionsThis polyclonal targets Human KLF4 Affinity Purified Ab
View all literature mentionsThis polyclonal targets Perilipin A
View all literature mentionsThis monoclonal targets Phospho-Smad2 (Ser465/467) (138D4) Rabbit mAb
View all literature mentionsThis monoclonal targets KLF4
View all literature mentionsThis polyclonal targets Human Galectin-3
View all literature mentionsThis polyclonal targets Green Fluorescent Protein (GFP)
View all literature mentionsThis monoclonal targets Eng
View all literature mentionsThis monoclonal targets CD90/Thy1
View all literature mentionsThis monoclonal targets CD73
View all literature mentionsCell line HEK293T/17 is a Transformed cell line with a species of origin Homo sapiens (Human)
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