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Pathogenesis of chronic rhinosinusitis with nasal polyps: role of IL-6 in airway epithelial cell dysfunction.

Emilie Bequignon | David Mangin | Justine Bécaud | Jennifer Pasquier | Christelle Angely | Mathieu Bottier | Estelle Escudier | Daniel Isabey | Marcel Filoche | Bruno Louis | Jean-François Papon | André Coste
Journal of translational medicine | 2020

Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by an alteration in airway epithelial cell functions including barrier function, wound repair mechanisms, mucociliary clearance. The mechanisms leading to epithelial cell dysfunction in nasal polyps (NPs) remain poorly understood. Our hypothesis was that among the inflammatory cytokines involved in NPs, IL-6 could alter epithelial repair mechanisms and mucociliary clearance. The aim of this study was to evaluate the in vitro effects of IL-6 on epithelial repair mechanisms in a wound repair model and on ciliary beating in primary cultures of Human Nasal Epithelial Cells (HNEC).

Pubmed ID: 32209102

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