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Publication

Hepatic de novo lipogenesis is suppressed and fat oxidation is increased by omega-3 fatty acids at the expense of glucose metabolism.

Charlotte J Green | Camilla Pramfalk | Catriona A Charlton | Pippa J Gunn | Thomas Cornfield | Michael Pavlides | Fredrik Karpe | Leanne Hodson
BMJ open diabetes research & care | 2020

Increased hepatic de novo lipogenesis (DNL) is suggested to be an underlying cause in the development of nonalcoholic fatty liver disease and/or insulin resistance. It is suggested that omega-3 fatty acids (FA) lower hepatic DNL. We investigated the effects of omega-3 FA supplementation on hepatic DNL and FA oxidation using a combination of human in vivo and in vitro studies.

Pubmed ID: 32188593

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Associated grants

  • Agency: British Heart Foundation, United Kingdom
    Id: FS/11/18/28633
  • Agency: British Heart Foundation, United Kingdom
    Id: FS/15/56/31645

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GraphPad Prism (tool)

RRID:SCR_002798

Statistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.

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Huh-7 (tool)

RRID:CVCL_0336

Cell line Huh-7 is a Cancer cell line with a species of origin Homo sapiens (Human)

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