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Here, we utilized spontaneous models of pancreatic and lung cancer to examine how neoantigenicity shapes tumor immunity and progression. As expected, neoantigen expression during lung adenocarcinoma development leads to T cell-mediated immunity and disease restraint. By contrast, neoantigen expression in pancreatic ductal adenocarcinoma (PDAC) results in exacerbation of a fibro-inflammatory microenvironment that drives disease progression and metastasis. Pathogenic TH17 responses are responsible for this neoantigen-induced tumor progression in PDAC. Underlying these divergent T cell responses in pancreas and lung cancer are differences in infiltrating conventional dendritic cells (cDCs). Overcoming cDC deficiency in early-stage PDAC leads to disease restraint, while restoration of cDC function in advanced PDAC restores tumor-restraining immunity and enhances responsiveness to radiation therapy.
Pubmed ID: 32183949
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Commercial supplier and developer of in vivo antibodies. Provides antibodies and antibody production services.
View all literature mentionsAn antibody supplier which banks and distributes hybridomas and monoclonal antibodies for use in research. The bank includes antibodies against targets such as GFP, transcription factors, stem cells, and human.
View all literature mentionsA portal that provides visualization, analysis and download of large-scale cancer genomics data sets.
View all literature mentionsSoftware tool for versatile matrix visualization and analysis. Program to generate heatmaps from input data. JavaScript matrix visualization and analysis.
View all literature mentionsThis monoclonal targets CD103
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View all literature mentionsThis monoclonal targets CD62L
View all literature mentionsThis monoclonal targets EGFR (phospho Y1068)
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis unknown targets Rat IgG1 kappa Isotype Control PE Clone RTK2071 (anti-KLH)
View all literature mentionsThis monoclonal targets CD366
View all literature mentionsThis monoclonal targets CD22
View all literature mentionsThis monoclonal targets CD14
View all literature mentionsThis monoclonal targets IL-10
View all literature mentionsThis monoclonal targets Ly-6C
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets CD141
View all literature mentionsThis monoclonal targets Granzyme B
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis isotype control targets Not Applicable
View all literature mentionsThis monoclonal targets CD80 (B7-1)
View all literature mentionsThis monoclonal targets CD86 (B7-2)
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD3e
View all literature mentionsThis monoclonal targets TCR gamma/delta
View all literature mentionsThis monoclonal targets CD15/SSEA-1
View all literature mentionsThis polyclonal targets MMP9 - Whole molecule
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View all literature mentionsThis unknown targets Ovalbumin
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View all literature mentionsThis monoclonal targets F4/80
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View all literature mentionsThis monoclonal targets CD274 (PD-L1, B7-H1)
View all literature mentionsThis unknown targets Rat IgG1 kappa Isotype Control Allophycocyanin Clone RTK2071 (anti-KLH)
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets F4/80
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets F4/80
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis monoclonal targets CD3e
View all literature mentionsThis unknown targets CD11c
View all literature mentionsThis monoclonal targets Keratin, type I; cytokeratin 19
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View all literature mentionsThis monoclonal targets CD163
View all literature mentionsThis monoclonal targets Mouse RORγt
View all literature mentionsThis monoclonal targets MHC Class I (H-2Kd/H-2Dd)
View all literature mentionsThis unknown targets
View all literature mentionsThis isotype control targets KLH
View all literature mentionsThis monoclonal targets Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204)
View all literature mentionsThis monoclonal targets CD107a (LAMP-1)
View all literature mentionsThis monoclonal targets CD45R
View all literature mentionsThis unknown targets CD24
View all literature mentionsThis monoclonal targets CD11b/Mac-1
View all literature mentionsThis monoclonal targets Ly6g
View all literature mentionsThis monoclonal targets CD68
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis monoclonal targets IL-17A
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View all literature mentionsThis monoclonal targets CD279 (PD-1)
View all literature mentionsThis monoclonal targets CD16/CD32
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View all literature mentionsThis monoclonal targets CD3
View all literature mentionsThis monoclonal targets CD44
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View all literature mentionsThis monoclonal targets PD-1 (CD279)
View all literature mentionsThis unknown targets CD45
View all literature mentionsThis monoclonal targets FOXP3
View all literature mentionsThis monoclonal targets CD3e
View all literature mentionsThis monoclonal targets CD38
View all literature mentionsThis monoclonal targets Ki-67
View all literature mentionsThis monoclonal targets Human Pan-Keratin
View all literature mentionsThis monoclonal targets T-bet
View all literature mentionsThis monoclonal targets Ki-67
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View all literature mentionsThis monoclonal targets CD252
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View all literature mentionsThis monoclonal targets CD25 (IL-2Rα)
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View all literature mentionsThis unknown targets CD56
View all literature mentionsThis monoclonal targets CD49b (Integrin alpha 2)
View all literature mentionsThis unknown targets CD206
View all literature mentionsThis monoclonal targets CD278
View all literature mentionsThis monoclonal targets CTLA-4 (CD152)
View all literature mentionsThis monoclonal targets CD8α
View all literature mentionsThis monoclonal targets CD45R (B220)
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View all literature mentionsThis monoclonal targets Anti-NK1.1 mouse
View all literature mentionsThis monoclonal targets MHC Class II (I-A/I-E)
View all literature mentionsThis monoclonal targets GFP
View all literature mentionsThis monoclonal targets CD40
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View all literature mentionsThis monoclonal targets I-A/I-E
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View all literature mentionsThis monoclonal targets CD24
View all literature mentionsThis monoclonal targets CD34
View all literature mentionsThis polyclonal targets Ki67 antibody - Proliferation Marker
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View all literature mentionsThis unknown targets
View all literature mentionsThis isotype control targets Trinitrophenol
View all literature mentionsThis monoclonal targets CD86 (B7-2)
View all literature mentionsMus musculus with name STOCK Tg(Pdx1-cre/Esr1*)#Dam/J from IMSR.
View all literature mentionsMus musculus with name C57BL/6-Tg(TcraTcrb)1100Mjb/J from IMSR.
View all literature mentionsMus musculus with name B6.Cg-Tg(TcraTcrb)425Cbn/J from IMSR.
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View all literature mentionsMus musculus with name C57BL/6J from IMSR.
View all literature mentionsSoftware for single-cell flow cytometry analysis. Its functions include management, display, manipulation, analysis and publication of the data stream produced by flow and mass cytometers.
View all literature mentionsThis monoclonal targets CD86 (B7-2)
View all literature mentionsA cloud-based platform which allows users to analyze, visualize, and archive multiparamter cytometry data for single-cell biology. Multiple single-cell data sets can be analyzed and visualized simultaneously with a variety of graphics, inlcuding Sunburst, SPADE, and viSNE. Users can store and back up related data such as protocols, microscopy images, and presentations and collaborate and share analysis and data sets with other Cytobank users. Cytobank also provides a variety of services and training sessions to assist with experiment workflow.
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View all literature mentionsMus musculus with name B6.129S6(C)-Zbtb46tm1.1Kmm/J from IMSR.
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