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Notch1 Has an Important Role in β-Cell Mass Determination and Development of Diabetes.

Young Sil Eom | A-Ryeong Gwon | Kyung Min Kwak | Jin-Young Youn | Heekyoung Park | Kwang-Won Kim | Byung-Joon Kim
Diabetes & metabolism journal | 2021

Notch signaling pathway plays an important role in regulating pancreatic endocrine and exocrine cell fate during pancreas development. Notch signaling is also expressed in adult pancreas. There are few studies on the effect of Notch on adult pancreas. Here, we investigated the role of Notch in islet mass and glucose homeostasis in adult pancreas using Notch1 antisense transgenic (NAS).

Pubmed ID: 32174059

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Associated grants

  • Agency: MHW,
    Id: RD 2013-03
  • Agency: MHW,
    Id: RD 2013-50
  • Agency: Ministry of Health and Welfare,
    Id: HI14C2539
  • Agency: Gachon University Gil Medical Center,
    Id: RD 2013-03
  • Agency: Gachon University Gil Medical Center,
    Id: RD 2013-50

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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