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Publication

Lactic acidosis induces resistance to the pan-Akt inhibitor uprosertib in colon cancer cells.

Emily M E Barnes | Yitao Xu | Adrian Benito | Lili Herendi | Alexandros P Siskos | Eric O Aboagye | Anke Nijhuis | Hector C Keun
British journal of cancer | 2020

Akt signalling regulates glycolysis and drives the Warburg effect in cancer, thus decreased glucose utilisation is a pharmacodynamic marker of Akt inhibition. However, cancer cells can utilise alternative nutrients to glucose for energy such as lactate, which is often elevated in tumours together with increased acidity. We therefore hypothesised that lactic acidosis may confer resistance to Akt inhibition.

Pubmed ID: 32152504

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Associated grants

  • Agency: Medical Research Council, United Kingdom
    Id: MR/N020782/1
  • Agency: EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020), International
    Id: 737978

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Promega (tool)

RRID:SCR_006724

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HCT 116 (tool)

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