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Long Leukocyte Telomere Length Is Associated with Increased Risks of Soft Tissue Sarcoma: A Mendelian Randomization Study.

Yifan Xu | Junfeng Xu | Haidee Chancoco | Maosheng Huang | Keila E Torres | Jian Gu
Cancers | 2020

Leukocyte telomere length (LTL) has been associated with the risks of several cancers in observational studies. Mendelian randomization (MR) studies, using genetic variants as instrumental variables, have also shown associations of genetically predicted LTL with cancer risks. In this study, we performed the first MR analysis on soft tissue sarcoma (STS) to investigate the causal relationship between LTL and the risk of STS.

Pubmed ID: 32150919

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Stata (tool)

RRID:SCR_012763

A Software resource for statistical analysis and presentation of graphics.

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Michigan Imputation Server (tool)

RRID:SCR_017579

Web server to implement whole genotype imputation workflow for efficient parallelization of computationally intensive tasks. Service for imputation that facilitates access to new reference panels and greatly improves user experience and productivity. Used to find haplotype segments and reference panel of sequenced genomes, assign genotypes at untyped markers, improve genome coverage, facilitate comparison and combination of studies that use different marker panels, increase power to detect genetic association, and guide fine mapping.

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