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Publication

Susceptibility of Rat Steatotic Liver to Ischemia-Reperfusion Is Treatable With Liver-Selective Matrix Metalloproteinase Inhibition.

Xiangdong Wang | Christopher J Walkey | Ana C Maretti-Mira | Lei Wang | Deborah L Johnson | Laurie D DeLeve
Hepatology (Baltimore, Md.) | 2020

This study examined whether enhanced susceptibility of steatotic liver to ischemia-reperfusion (I/R) injury is due to impaired recruitment of bone marrow (BM) progenitors of liver sinusoidal endothelial cells (LSECs, also called sinusoidal endothelial cell progenitor cells [sprocs]) with diminished repair of injured LSECs and whether restoring signaling to recruit BM sprocs reduces I/R injury.

Pubmed ID: 32060938

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Associated grants

  • Agency: NIDDK NIH HHS, United States
    Id: P30 DK048522
  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK046357
  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK066423
  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK100580
  • Agency: NIDDK NIH HHS, United States
    Id: 100580
  • Agency: NIDDK NIH HHS, United States
    Id: 46357

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LEW-Tg(CAG-EGFP)YsRrrc (organism)

RRID:RRRC_00296

Rattus norvegicus with name LEW-Tg(CAG-EGFP)YsRrrc from RGD.

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The PRECISE-TBI toolbox are a collection tools and resources to increase rigor and reproducibility with Traumatic Brain Injury within the PRE Clinical Interagency reSearch resourcE - Traumatic Brain Injury (PRECISE-TBI). Please learn more about PRECISE-TBI at https://www.precise-tbi.org

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