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Notch signaling controls proliferation of multipotent pancreatic progenitor cells (MPCs) and their segregation into bipotent progenitors (BPs) and unipotent pro-acinar cells (PACs). Here, we showed that fast ultradian oscillations of the ligand Dll1 and the transcriptional effector Hes1 were crucial for MPC expansion, and changes in Hes1 oscillation parameters were associated with selective adoption of BP or PAC fate. Conversely, Jag1, a uniformly expressed ligand, restrained MPC growth. However, when its expression later segregated to PACs, Jag1 became critical for the specification of all but the most proximal BPs, and BPs were entirely lost in Jag1; Dll1 double mutants. Anatomically, ductal morphogenesis and organ architecture are minimally perturbed in Jag1 mutants until later stages, when ductal remodeling fails, and signs of acinar-to-ductal metaplasia appear. Our study thus uncovers that oscillating Notch activity in the developing pancreas, modulated by Jag1, is required to coordinate MPC growth and fate.
Pubmed ID: 32059775
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An antibody supplier which banks and distributes hybridomas and monoclonal antibodies for use in research. The bank includes antibodies against targets such as GFP, transcription factors, stem cells, and human.
View all literature mentionsMus musculus with name ICR-Tg(Hes1-luc2/Hes1)1Imayo from IMSR.
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View all literature mentionsThis polyclonal targets Porcine pancreatic insulin
View all literature mentionsThis polyclonal targets Rat Notch-2 Affinity Purified Ab
View all literature mentionsThis monoclonal targets E-cadherin
View all literature mentionsThis monoclonal targets MUC1
View all literature mentionsThis monoclonal targets NOTCH1
View all literature mentionsThis monoclonal targets Homeobox protein Nkx-6.1; Nkx6.1
View all literature mentionsThis polyclonal targets Rat DLL1
View all literature mentionsThis polyclonal targets alpha-Amylase antibody produced in rabbit
View all literature mentionsThis monoclonal targets Jagged1
View all literature mentionsThis polyclonal targets Mouse Carboxypeptidase A1 Affinity Purified Ab
View all literature mentionsThis monoclonal targets Keratin, type I; cytokeratin 19
View all literature mentionsThis polyclonal targets GFP
View all literature mentionsThis monoclonal targets Tubulin
View all literature mentionsThis polyclonal targets RFP
View all literature mentionsThis polyclonal targets Insulin
View all literature mentionsThis monoclonal targets Tubulin Acetylated
View all literature mentionsThis monoclonal targets MIST1
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View all literature mentionsThis unknown targets Glucagon
View all literature mentionsThis polyclonal targets Ngn3 (NCBI Gene ID: 11925)
View all literature mentionsThis polyclonal targets PDX1 (NCBI Gene ID: 18609)
View all literature mentionsThis polyclonal targets Somatostatin
View all literature mentionsThis polyclonal targets PKCZ
View all literature mentionsThis monoclonal targets Glucagon
View all literature mentionsThis polyclonal targets Mouse Notch-1
View all literature mentionsThis unknown targets raised against Rasied Against a peptide mapping at the C-terminus of HNF-1_ of human origin.
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View all literature mentionsMus musculus with name STOCK Ptf1atm1.1(cre)Cvw/Mmnc from MMRRC.
View all literature mentionsMus musculus with name B6.129-Dll1tm1Gos/J from IMSR.
View all literature mentionsMus musculus with name ICR;129-Hes1tm1Fgu/KagRbrc from IMSR.
View all literature mentionsMus musculus with name B6.129S-Jag1tm2Grid/SjJ from IMSR.
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View all literature mentionsMus musculus with name B6.Cg-Gt(ROSA)26Sortm3(CAG-EYFP)Hze/J from IMSR.
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View all literature mentionsMus musculus with name STOCK Tg(Hnf1b-cre/ERT2)1Jfer/J from IMSR.
View all literature mentionsSoftware package as distribution of ImageJ and ImageJ2 together with Java, Java3D and plugins organized into coherent menu structure. Used to assist research in life sciences.
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View all literature mentionsMus musculus with name B6.129X1-Gt(ROSA)26Sortm1(EYFP)Cos/J from IMSR.
View all literature mentionsMus musculus with name STOCK Notch1tm4(cre)Rko/J from IMSR.
View all literature mentionsImaris provides range of capabilities for working with three dimensional images. Uses flexible editing and processing functions, such as interactive surface rendering and object slicing capabilities. And output to standard TIFF, Quicktime and AVI formats. Imaris accepts virtually all image formats that are used in confocal microscopy and many of those used in wide-field image acquisition.
View all literature mentionsMus musculus with name B6.129S1-Jag1tm1Grid/J from IMSR.
View all literature mentionsSoftware for image processing, analysis, and editing. The software includes features such as touch capabilities, a customizable toolbar, 2D and 3D image merging, and Cloud access and options.
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View all literature mentionsUser interface software for Carl Zeiss light microscopy imaging systems. ZEN is the universal user interface you will see on every imaging system from ZEISS. After selecting fluorophore, ZEN applies the necessary settings to collect and organize data.
View all literature mentionsSoftware application with data analysis tools and spreadsheet templates to track and visualize data. It is used to manage and process data.
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