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P7C3-A20 alleviates fatty liver by shaping gut microbiota and inducing FGF21/FGF1, via the AMP-activated protein kinase/CREB regulated transcription coactivator 2 pathway.

Xia Hua | Di-Yang Sun | Wen-Jie Zhang | Jiang-Tao Fu | Jie Tong | Si-Jia Sun | Fei-Yan Zeng | Shen-Xi Ouyang | Guo-Yan Zhang | Shu-Na Wang | Dong-Jie Li | Chao-Yu Miao | Pei Wang
British journal of pharmacology | 2021

Non-alcoholic fatty liver disease (NAFLD) is a worldwide public health problem with no established pharmacological therapy. Here, we explored the potential benefit of P7C3-A20, a novel aminopropyl carbazole compound with neuroprotective activity, in a NAFLD model, induced in mice by a high-fat diet (HFD).

Pubmed ID: 32037512

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GraphPad Prism (software resource)

RRID:SCR_002798

Statistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.

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