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The incretin hormone glucagon-like peptide-1 (GLP-1) is secreted from intestinal L-cells upon nutrient intake. While recent evidence has shown that GLP-1 is released in a circadian manner in rats, whether this occurs in mice and if this pattern is regulated by the circadian clock remain to be elucidated. Furthermore, although circadian GLP-1 secretion parallels expression of the core clock gene Bmal1, the link between the two remains largely unknown. Secretagogin (Scgn) is an exocytotic SNARE regulatory protein that demonstrates circadian expression and is essential for insulin secretion from β-cells. The objective of the current study was to establish the necessity of the core clock gene Bmal1 and the SNARE protein SCGN as essential regulators of circadian GLP-1 secretion.
Pubmed ID: 31918914
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Software package for quantifying gene and isoform abundances from single end or paired end RNA Seq data. Accurate transcript quantification from RNA Seq data with or without reference genome. Used for accurate quantification of gene and isoform expression from RNA-Seq data.
View all literature mentionsHuman and mouse genome annotation project which aims to identify all gene features in the human genome using computational analysis, manual annotation, and experimental validation.
View all literature mentionsMus musculus with name C57BL/6J from IMSR.
View all literature mentionsMus musculus with name C57BL/6J-Tg(Per1-VLUC.Bmal1-FLUC)CZ205-4Obs/Rbrc from IMSR.
View all literature mentionsMus musculus with name C57BL/6J-Tg(Per1-VLUC.Bmal1-FLUC)CZ205-4Obs/Rbrc from IMSR.
View all literature mentionsMus musculus with name C57BL/6J from IMSR.
View all literature mentionsMus musculus with name C57BL/6J-Tg(Per1-VLUC.Bmal1-FLUC)CZ205-4Obs/Rbrc from IMSR.
View all literature mentionsMus musculus with name C57BL/6J-Tg(Per1-VLUC.Bmal1-FLUC)CZ205-4Obs/Rbrc from IMSR.
View all literature mentionsMus musculus with name C57BL/6J-Tg(Per1-VLUC.Bmal1-FLUC)CZ205-4Obs/Rbrc from IMSR.
View all literature mentions