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SOD2 ameliorates pulmonary hypertension in a murine model of sleep apnea via suppressing expression of NLRP3 in CD11b+ cells.

Cuiping Fu | Shengyu Hao | Zilong Liu | Liang Xie | Xu Wu | Xiaodan Wu | Shanqun Li
Respiratory research | 2020

High prevalence of obstructive sleep apnea (OSA) in the pulmonary hypertension (PH) population suggests that chronic intermittent hypoxia (CIH) is an important pathogenic factor of PH. However, the exact mechanism of CIH induced PH is not clear. One of the molecules that plays a key role in regulating pulmonary artery function under hypoxic conditions is superoxide dismutase 2 (SOD2).

Pubmed ID: 31915037

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