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Publication

HDAC5-mediated deacetylation and nuclear localisation of SOX9 is critical for tamoxifen resistance in breast cancer.

Yue Xue | Wenwen Lian | Jiaqi Zhi | Wenjuan Yang | Qianjin Li | Xingyi Guo | Jiahao Gao | Hao Qu | Weiqiang Lin | Zhongqi Li | Lihua Lai | Qingqing Wang
British journal of cancer | 2019

Tamoxifen resistance remains a significant clinical challenge for the therapy of ER-positive breast cancer. It has been reported that the upregulation of transcription factor SOX9 in ER+ recurrent cancer is sufficient for tamoxifen resistance. However, the mechanisms underlying the regulation of SOX9 remain largely unknown.

Pubmed ID: 31690832

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Proteintech Group (tool)

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Proteintech Europe Ltd is an ISO 9001:2008 certified company

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MDA-MB-231 (tool)

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T-47D (tool)

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MCF-7 (tool)

RRID:CVCL_0031

Cell line MCF-7 is a Cancer cell line with a species of origin Homo sapiens (Human)

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