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Volumetric Prefrontal Cortex Alterations in Patients With Alcohol Dependence and the Involvement of Self-Control.

Annika Rosenthal | Anne Beck | Evangelos Zois | Sabine Vollstädt-Klein | Henrik Walter | Falk Kiefer | Falk W Lohoff | Katrin Charlet
Alcoholism, clinical and experimental research | 2019

Aspects of self-control such as sensation seeking and impaired impulse control have been implicated in alcohol dependence (ALC). Conversely, sensation seeking has been ascribed a possible protective role in stress-related psychopathologies. We therefore examined gray matter (GM) morphology in individuals with ALC, focusing on differences in prefrontal regions that have been associated with self-control. Additionally, we accounted for differences in lifetime alcohol intake regarding self-control measures and cortical structures in ALC patients.

Pubmed ID: 31688973

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Associated grants

  • Agency: Bundesministerium für Gesundheit, International
    Id: ZMVI1-2516DSM223
  • Agency: Intramural NIH HHS, United States
    Id: Z99 AA999999
  • Agency: Deutsche Forschungsgemeinschaft, International
    Id: CH 1936/1-1
  • Agency: Bundesministerium für Bildung und Forschung, International
    Id: FKZ 01GS08159
  • Agency: Intramural NIH HHS, United States
    Id: ZIA AA000242
  • Agency: Intramural NIH HHS, United States
    Id: ZIA AA000242-04
  • Agency: Bundesministerium für Bildung und Forschung, International
    Id: FKZ 01ZX1311E
  • Agency: Deutsche Forschungsgemeinschaft, International
    Id: HE2597/14-1
  • Agency: Deutsche Forschungsgemeinschaft, International
    Id: ZI1119/3-1

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Neuromorphometrics (tool)

RRID:SCR_005656

Web tool for brain measurement services. Used for modeling living human brain and make quantitative measurements of volume, shape, and location of specific neuroanatomical structures using given MRI brain scans. Automated analyses are manually guided, inspected and certified by a neuroanatomical expert. Resource of neuroanatomically labeled MRI brain scans database. Resource for neuroanatomical localization and identification: NeuAtlas.

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