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Publication

Interleukin-8 promotes integrin β3 upregulation and cell invasion through PI3K/Akt pathway in hepatocellular carcinoma.

Fengkai Sun | Jianping Wang | Qi Sun | Fanni Li | Hengjun Gao | Lin Xu | Jiao Zhang | Xiaoyan Sun | Yanan Tian | Qiujie Zhao | Huimin Shen | Kai Zhang | Jun Liu
Journal of experimental & clinical cancer research : CR | 2019

Interleukin-8 (IL-8) plays a vital role in the invasion and metastasis of hepatocellular carcinoma (HCC), and is closely associated with poor prognosis of HCC patients. Integrin αvβ3, a member of the integrin family, has been reported to be overexpressed in cancer tissues and mediate the invasion and metastasis of HCC cells. However, the relationship between IL-8 and integrin αvβ3 in HCC and the underlying mechanism of IL-8 and integrin αvβ3 in the invasion of HCC remains unclear.

Pubmed ID: 31684995

Research resources used in this publication

None found

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Associated grants

  • Agency: Natural Science Foundation of Shandong Province,
    Id: ZR2017BH072
  • Agency: Natural Science Foundation of Shandong Province,
    Id: ZR2017BH095
  • Agency: Natural Science Foundation of Shandong Province,
    Id: ZR2014P065
  • Agency: National Natural Science Foundation of China,
    Id: 81702362
  • Agency: National Natural Science Foundation of China,
    Id: 81803026
  • Agency: National Natural Science Foundation of China,
    Id: 81802379
  • Agency: Jinan Science and Technology Bureau,
    Id: 201805029

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

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