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Lysyl oxidase promotes liver metastasis of gastric cancer via facilitating the reciprocal interactions between tumor cells and cancer associated fibroblasts.

Qing Li | Chun-Chao Zhu | Bo Ni | Zi-Zhen Zhang | Shu-Heng Jiang | Li-Peng Hu | Xu Wang | Xiao-Xin Zhang | Pei-Qi Huang | Qin Yang | Jun Li | Jian-Ren Gu | Jia Xu | Kathy Qian Luo | Gang Zhao | Zhi-Gang Zhang
EBioMedicine | 2019

Liver is one of the most preferred destinations of distant metastasis in gastric cancer (GC). As effective treatment is still limited, the prognosis of GC patients bearing liver metastasis is poor. We filter out lysyl oxidase (LOX) to study its function in the tumor microenvironment (TME) and seek for potential therapeutic targets.

Pubmed ID: 31678002

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BioVision (tool)

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HGC-27 (tool)

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