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Publication

Interleukin 10 promotes macrophage uptake of HDL and LDL by stimulating fluid-phase endocytosis.

Diego Lucero | Promotto Islam | Lita A Freeman | Xueting Jin | Milton Pryor | Jingrong Tang | Howard S Kruth | Alan T Remaley
Biochimica et biophysica acta. Molecular and cell biology of lipids | 2020

Highly elevated plasma levels of interleukin-10 (IL-10) are causally associated with "Disappearing HDL Syndrome" and low plasma LDL-cholesterol, but the underlying mechanism is poorly understood. Fluid-phase endocytosis, a process highly dependent on actin dynamics, enables cells to internalize relatively high amounts of extracellular fluids and solutes. We sought to investigate whether IL-10 induces lipoprotein uptake by fluid-phase endocytosis in macrophages.

Pubmed ID: 31676439

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Associated grants

  • Agency: Intramural NIH HHS, United States
    Id: ZIA HL006095-09

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