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Publication

MSU Crystals induce sterile IL-1β secretion via P2X7 receptor activation and HMGB1 release.

Ygor Marinho | Camila Marques-da-Silva | Patricia Teixeira Santana | Mariana Martins Chaves | Augusto Shuiti Tamura | Thuany Prado Rangel | Isabel Virgínia Gomes-E-Silva | Marília Zaluar Passos Guimarães | Robson Coutinho-Silva
Biochimica et biophysica acta. General subjects | 2020

The mechanism by which monosodium urate (MSU) crystals induce inflammation is not completely understood. Few studies have shown that MSU is capable of stimulating the release of IL-1β in the absence of LPS treatment. The purinergic P2X7 receptor is involved in the release of IL-1β in inflammatory settings caused by crystals, as is the case in silicosis.

Pubmed ID: 31676289

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