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Scaling computational genomics to millions of individuals with GPUs.

Amaro Taylor-Weiner | François Aguet | Nicholas J Haradhvala | Sager Gosai | Shankara Anand | Jaegil Kim | Kristin Ardlie | Eliezer M Van Allen | Gad Getz
Genome biology | 2019

Current genomics methods are designed to handle tens to thousands of samples but will need to scale to millions to match the pace of data and hypothesis generation in biomedical science. Here, we show that high efficiency at low cost can be achieved by leveraging general-purpose libraries for computing using graphics processing units (GPUs), such as PyTorch and TensorFlow. We demonstrate > 200-fold decreases in runtime and ~ 5-10-fold reductions in cost relative to CPUs. We anticipate that the accessibility of these libraries will lead to a widespread adoption of GPUs in computational genomics.

Pubmed ID: 31675989

Research resources used in this publication

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Associated grants

  • Agency: NIGMS NIH HHS, United States
    Id: T32 GM008313
  • Agency: NHGRI NIH HHS, United States
    Id: T32 HG002295

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This is a list of tools and resources that we have found mentioned in this publication.


PLINK (tool)

RRID:SCR_001757

Open source whole genome association analysis toolset, designed to perform range of basic, large scale analyses in computationally efficient manner. Used for analysis of genotype/phenotype data. Through integration with gPLINK and Haploview, there is some support for subsequent visualization, annotation and storage of results. PLINK 1.9 is improved and second generation of the software.

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Fastqtl (tool)

RRID:SCR_016093

Software for mapping of molecular phenotypes that implements a new permutation scheme to accurately and rapidly correct for multiple-testing at both the genotype and phenotype levels in large-scale datasets. It is used to discover quantitative trait loci, multi-dimensional genomic datasets combining DNA-seq and ChiP-/RNA-seq.

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