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Phospholipids are A Potentially Important Source of Tissue Biomarkers for Hepatocellular Carcinoma: Results of a Pilot Study Involving Targeted Metabolomics.

Erin B Evangelista | Sandi A Kwee | Miles M Sato | Lu Wang | Christoph Rettenmeier | Guoxiang Xie | Wei Jia | Linda L Wong
Diagnostics (Basel, Switzerland) | 2019

Hepatocellular carcinoma (HCC) pathogenesis involves the alteration of multiple liver-specific metabolic pathways. We systematically profiled cancer- and liver-related classes of metabolites in HCC and adjacent liver tissues and applied supervised machine learning to compare their potential yield for HCC biomarkers.

Pubmed ID: 31671805

Research resources used in this publication

None found

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Antibodies used in this publication

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Associated grants

  • Agency: NIH HHS, United States
    Id: R01CA161209-06
  • Agency: NIMHD NIH HHS, United States
    Id: U54 MD007601
  • Agency: NIMHD NIH HHS, United States
    Id: U54 MD007584
  • Agency: NCI NIH HHS, United States
    Id: P30 CA071789
  • Agency: NCI NIH HHS, United States
    Id: R01 CA161209

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This is a list of tools and resources that we have found mentioned in this publication.


MetaboAnalyst (tool)

RRID:SCR_015539

Web server for statistical, functional and integrative analysis of metabolomics data. Web based tool suite used for metabolomic data processing, normalization, multivariate statistical analysis, and data annotation, biomarker discovery and classification.

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MetaboAnalystR (tool)

RRID:SCR_016723

Software R package for comprehensive analysis of metabolomics data. Contains the R functions and libraries underlying MetaboAnalyst web server, including functions for metabolomic data analysis, visualization, and functional interpretation.

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