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Tumor cells hijack enteric glia to activate colon cancer stem cells and stimulate tumorigenesis.

Simon Valès | Gregory Bacola | Mandy Biraud | Mélissa Touvron | Anne Bessard | Fanny Geraldo | Kelsie A Dougherty | Shaian Lashani | Céline Bossard | Mathurin Flamant | Emilie Duchalais | Séverine Marionneau-Lambot | Thibauld Oullier | Lisa Oliver | Michel Neunlist | François M Vallette | Laurianne Van Landeghem
EBioMedicine | 2019

Colon cancer stem cells (CSCs), considered responsible for tumor initiation and cancer relapse, are constantly exposed to regulatory cues emanating from neighboring cells present in the tumor microenvironment. Among these cells are enteric glial cells (EGCs) that are potent regulators of the epithelium functions in a healthy intestine. However, whether EGCs impact CSC-driven tumorigenesis remains unknown.

Pubmed ID: 31662289

Associated grants

  • Agency: NCI NIH HHS, United States
    Id: P30 CA016086
  • Agency: NIDDK NIH HHS, United States
    Id: P30 DK034987

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