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Publication

Gpr17 deficiency in POMC neurons ameliorates the metabolic derangements caused by long-term high-fat diet feeding.

Austin M Reilly | Shudi Zhou | Sunil K Panigrahi | Shijun Yan | Jason M Conley | Patrick L Sheets | Sharon L Wardlaw | Hongxia Ren
Nutrition & diabetes | 2019

Proopiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (ARH) control energy homeostasis by sensing hormonal and nutrient cues and activating secondary melanocortin sensing neurons. We identified the expression of a G protein-coupled receptor, Gpr17, in the ARH and hypothesized that it contributes to the regulatory function of POMC neurons on metabolism.

Pubmed ID: 31611548

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Associated grants

  • Agency: NIDDK NIH HHS, United States
    Id: P30 DK097512
  • Agency: U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases), International
    Id: R00DK09824
  • Agency: U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases), International
    Id: P30DK97512
  • Agency: NIDDK NIH HHS, United States
    Id: R00 DK098294
  • Agency: U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS), International
    Id: UL1TR002529
  • Agency: NIDDK NIH HHS, United States
    Id: T32 DK064466

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GraphPad Prism (tool)

RRID:SCR_002798

Statistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.

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Millipore (tool)

RRID:SCR_008983

An Antibody supplier

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B6.Cg-Slc2a9tm1.1Thor Alb/ThorOrl (tool)

RRID:IMSR_EM:12351

Mus musculus with name B6.Cg-Slc2a9tm1.1Thor Alb/ThorOrl from IMSR.

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