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Publication

The metabolic and vascular protective effects of olive (Olea europaea L.) leaf extract in diet-induced obesity in mice are related to the amelioration of gut microbiota dysbiosis and to its immunomodulatory properties.

Teresa Vezza | Alba Rodríguez-Nogales | Francesca Algieri | José Garrido-Mesa | Miguel Romero | Manuel Sánchez | Marta Toral | Beatriz Martín-García | Ana M Gómez-Caravaca | David Arráez-Román | Antonio Segura-Carretero | Vicente Micol | Federico García | María Pilar Utrilla | Juan Duarte | María Elena Rodríguez-Cabezas | Julio Gálvez
Pharmacological research | 2019

Many studies have showed the beneficial effects of the olive (Olea europaea) leaf extract (OLE) in experimental models of metabolic syndrome, which have been ascribed to the presence of phenolic compounds, like oleuropeoside. This study evaluated the effects of a chemically characterized OLE in high fat diet (HFD)-induced obesity in mice, describing the underlying mechanisms involved in the beneficial effects, with special attention to vascular dysfunction and gut microbiota composition.

Pubmed ID: 31610229

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