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KOFFI and Anabel 2.0-a new binding kinetics database and its integration in an open-source binding analysis software.

Leo William Norval | Stefan Daniel Krämer | Mingjie Gao | Tobias Herz | Jianyu Li | Christin Rath | Johannes Wöhrle | Stefan Günther | Günter Roth
Database : the journal of biological databases and curation | 2019

The kinetics of featured interactions (KOFFI) database is a novel tool and resource for binding kinetics data from biomolecular interactions. While binding kinetics data are abundant in literature, finding valuable information is a laborious task. We used text extraction methods to store binding rates (association, dissociation) as well as corresponding meta-information (e.g. methods, devices) in a novel database. To date, over 270 articles were manually curated and binding data on over 1705 interactions was collected and stored in the (KOFFI) database. Moreover, the KOFFI database application programming interface was implemented in Anabel (open-source software for the analysis of binding interactions), enabling users to directly compare their own binding data analyses with related experiments described in the database.

Pubmed ID: 31608948

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Django (tool)

RRID:SCR_012855

Django is a high-level Python Web framework that encourages rapid development and clean, pragmatic design. Developed four years ago by a fast-moving online-news operation, Django was designed to handle two challenges: the intensive deadlines of a newsroom and the stringent requirements of the experienced Web developers who wrote it. It lets you build high-performing, elegant Web applications quickly. Django focuses on automating as much as possible and adhering to the DRY principle.

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