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Plasma neurofilament light chain and amyloid-β are associated with the kynurenine pathway metabolites in preclinical Alzheimer's disease.

Pratishtha Chatterjee | Henrik Zetterberg | Kathryn Goozee | Chai K Lim | Kelly R Jacobs | Nicholas J Ashton | Abdul Hye | Steve Pedrini | Hamid R Sohrabi | Tejal Shah | Prita R Asih | Preeti Dave | Kaikai Shen | Kevin Taddei | David B Lovejoy | Gilles J Guillemin | Kaj Blennow | Ralph N Martins
Journal of neuroinflammation | 2019

Blood markers indicative of neurodegeneration (neurofilament light chain; NFL), Alzheimer's disease amyloid pathology (amyloid-β; Aβ), and neuroinflammation (kynurenine pathway; KP metabolites) have been investigated independently in neurodegenerative diseases. However, the association of these markers of neurodegeneration and AD pathology with neuroinflammation has not been investigated previously. Therefore, the current study examined whether NFL and Aβ correlate with KP metabolites in elderly individuals to provide insight on the association between blood indicators of neurodegeneration and neuroinflammation.

Pubmed ID: 31601232

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