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Decrements of body mass index are associated with poor outcomes of idiopathic pulmonary fibrosis patients.

Tejaswini Kulkarni | Kaiyu Yuan | Thi K Tran-Nguyen | Young-Il Kim | Joao A de Andrade | Tracy Luckhardt | Vincent G Valentine | Daniel J Kass | Steven R Duncan
PloS one | 2019

The processes that result in progression of idiopathic pulmonary fibrosis (IPF) remain enigmatic. Moreover, the course of this disease can be highly variable and difficult to accurately predict. We hypothesized analyses of body mass index (BMI), a simple, routine clinical measure, may also have prognostic value in these patients, and might provide mechanistic insights. We investigated the associations of BMI changes with outcome, plasma adipokines, and adaptive immune activation among IPF patients.

Pubmed ID: 31584949

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Associated grants

  • Agency: NHLBI NIH HHS, United States
    Id: R01 HL119960
  • Agency: NHLBI NIH HHS, United States
    Id: R01 HL126990

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